Koji Nishifuji Selected Research

Exfoliatins

8/2011	Staphylococcus pseudintermedius exfoliative toxin EXI selectively digests canine desmoglein 1 and causes subcorneal clefts in canine epidermis.
11/2010	Identification of a novel Staphylococcus pseudintermedius exfoliative toxin gene and its prevalence in isolates from canines with pyoderma and healthy dogs.
9/2010	Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation.
11/2005	Staphylococcus hyicus exfoliative toxins selectively digest porcine desmoglein 1.
10/2005	Cloning of swine desmoglein 1 and its direct proteolysis by Staphylococcus hyicus exfoliative toxins isolated from pigs with exudative epidermitis.
11/2004	Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome.
2/2004	Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1.
5/2002	Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1.

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Koji Nishifuji Research Topics

Disease

15	Pemphigus (Pemphigus Vulgaris) 01/2018 - 08/2002
8	Skin Diseases (Skin Disease) 12/2021 - 08/2004
8	Blister (Bulla) 09/2010 - 05/2002
6	Impetigo (Impetigo Contagiosa) 01/2019 - 05/2002
5	Pyoderma 02/2013 - 01/2002
5	Atopic Dermatitis (Atopic Eczema) 02/2013 - 11/2004
5	Staphylococcal Scalded Skin Syndrome (Ritter's Disease) 08/2011 - 05/2002
4	Infections 07/2018 - 11/2010
3	Dermatitis 07/2018 - 01/2002
2	Inflammation (Inflammations) 01/2022 - 12/2021
2	Ichthyosis (Xeroderma) 02/2013 - 02/2013
2	Pruritus (Itching) 10/2008 - 01/2002
1	Folliculitis (Sycosis) 02/2022
1	Hypertrophy 01/2022
1	Cardiomyopathies (Cardiomyopathy) 01/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Renal Insufficiency (Renal Failure) 01/2022
1	Edema (Dropsy) 01/2022
1	Contact Dermatitis (Eczema, Contact) 12/2021
1	Virus Diseases (Viral Diseases) 01/2021
1	Food Hypersensitivity (Food Allergy) 09/2020
1	Hypersensitivity (Allergy) 09/2020
1	Staphylococcal Skin Infections 11/2019
1	Mastitis 11/2019
1	Localized Scleroderma (Morphea) 07/2018
1	Enteritis 07/2016
1	Eosinophilic enteropathy 07/2016
1	Lymphoma (Lymphomas) 12/2013
1	Oral Ulcer (Mouth Ulcer) 04/2013
1	Hyperplasia 02/2013
1	5 Atopic Dermatitis 10/2009
1	Epidermolysis Bullosa 10/2007

Drug/Important Bio-Agent (IBA)

9	Desmoglein 3IBA 01/2018 - 05/2002
9	AutoantibodiesIBA 04/2013 - 08/2004
8	Desmoglein 1IBA 11/2019 - 05/2002
8	DesmogleinsIBA 04/2012 - 08/2004
8	ExfoliatinsIBA 08/2011 - 05/2002
6	Immunoglobulin G (IgG)IBA 04/2013 - 08/2004
5	AntibodiesIBA 02/2013 - 09/2003
4	AntigensIBA 07/2018 - 01/2002
4	Cell Adhesion MoleculesIBA 01/2018 - 11/2004
4	Cadherins (E-Cadherin)IBA 01/2009 - 05/2002
3	CytokinesIBA 12/2021 - 11/2004
3	LipidsIBA 02/2013 - 10/2009
3	EpitopesIBA 04/2012 - 10/2003
3	Peptides (Polypeptides)IBA 09/2010 - 01/2002
2	AllergensIBA 09/2020 - 11/2004
2	EnzymesIBA 09/2020 - 10/2009
2	ImmunosorbentsIBA 09/2020 - 10/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 07/2018 - 01/2002
2	AutoantigensIBA 01/2018 - 02/2011
2	Proteins (Proteins, Gene)FDA Link 02/2013 - 10/2007
2	CeramidesIBA 09/2011 - 10/2009
1	Carbonated WaterIBA 02/2022
1	salvianolic acid BIBA 01/2022
1	salicylhydroxamic acid (SHAM)IBA 01/2022
1	HaptensIBA 12/2021
1	Dinitrochlorobenzene (DNCB)IBA 12/2021
1	Viral ProteinsIBA 01/2021
1	protease SIBA 01/2021
1	Phosphopyruvate Hydratase (Enolase)IBA 09/2020
1	Immunoglobulin E (IgE)IBA 09/2020
1	TropomyosinIBA 09/2020
1	Serine Proteases (Serine Protease)IBA 11/2019
1	Virulence Factors (Pathogenicity Factors)IBA 11/2019
1	endolysinIBA 01/2019
1	CollagenIBA 07/2018
1	Interleukin-2 (IL2)IBA 01/2018
1	Prednisolone (Predate)FDA LinkGeneric 07/2016
1	Chemokine ReceptorsIBA 12/2013
1	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2013
1	cefovecinIBA 02/2013
1	AgarIBA 02/2013
1	5'-N-methylcarboxamideadenosineIBA 02/2013
1	DNA (Deoxyribonucleic Acid)IBA 08/2011
1	CoagulaseIBA 12/2010
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2008
1	Collagen Type VIIIBA 10/2007
1	Interferon-gamma (Interferon, gamma)IBA 04/2007
1	Protein Isoforms (Isoforms)IBA 08/2004
1	Pharmaceutical PreparationsIBA 08/2002
1	Anti-Allergic Agents (Antiallergic Agents)IBA 01/2002

Therapy/Procedure

4	Therapeutics 12/2021 - 01/2002
2	Immunotherapy 11/2004 - 01/2002
1	Nephrectomy 01/2022
1	Phototherapy (Light Therapy) 12/2021
1	Phage Therapy 01/2016
1	Euthanasia (Mercy Killing) 04/2013